{"created":"2023-06-19T07:24:58.866239+00:00","id":377,"links":{},"metadata":{"_buckets":{"deposit":"993aa8af-bf08-491f-ad69-15c4fcd573eb"},"_deposit":{"created_by":3,"id":"377","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"377"},"status":"published"},"_oai":{"id":"oai:mpu.repo.nii.ac.jp:00000377","sets":["37:56:57"]},"author_link":["792","794","796","785","799","797","783","798","789","790","787","795","788","779","782","793","784","781","791","800","802","780","801","786"],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"26","bibliographicPageStart":"12","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"宮崎県立看護大学研究紀要"},{"bibliographic_title":"Journal of Miyazaki Prefectural Nursing University","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"島内, 千恵子"}],"nameIdentifiers":[{"nameIdentifier":"779","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"重田, 真里"}],"nameIdentifiers":[{"nameIdentifier":"780","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"毛利, 千祥"}],"nameIdentifiers":[{"nameIdentifier":"781","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"勝野, 絵梨奈"}],"nameIdentifiers":[{"nameIdentifier":"782","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000014600602","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000014600602"}]},{"creatorNames":[{"creatorName":"川口, 真紀子"}],"nameIdentifiers":[{"nameIdentifier":"783","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"井田, 孝志"}],"nameIdentifiers":[{"nameIdentifier":"784","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"橘, 宣祥"}],"nameIdentifiers":[{"nameIdentifier":"785","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"井上, 松久"}],"nameIdentifiers":[{"nameIdentifier":"786","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_7":{"attribute_name":"著者名よみ","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"シマウチ, チエコ"}],"nameIdentifiers":[{"nameIdentifier":"787","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"シゲタ, マリ"}],"nameIdentifiers":[{"nameIdentifier":"788","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"モウリ, チヒロ"}],"nameIdentifiers":[{"nameIdentifier":"789","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"カツノ, エリナ"}],"nameIdentifiers":[{"nameIdentifier":"790","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"カワグチ, マキコ"}],"nameIdentifiers":[{"nameIdentifier":"791","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"イダ, タカシ"}],"nameIdentifiers":[{"nameIdentifier":"792","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"タチバナ, ノブヨシ"}],"nameIdentifiers":[{"nameIdentifier":"793","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"イノウエ, マツヒサ"}],"nameIdentifiers":[{"nameIdentifier":"794","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shimauchi, Chieko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"795","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shigeta, Mari","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"796","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mouri, Chihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"797","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Katsuno, Erina","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"798","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawaguchi, Makiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"799","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ida, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"800","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tachibana, Nobuyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"801","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inoue, Matsuhisa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"802","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"1990年代の初め日本全国の病院でメチシリン耐性黄色ブドウ球菌methicillin-resistant Staphylococcus aureus(MRSA)の院内感染が問題となったが,施設や地域を超えて同一菌株が広がったのか,各施設で異なる菌株が流行していたのか,明かではない。そこで,1992～93年MRSA全国調査で,39医療施設から集めた872株のうち,保存状態が良好であった866株について,コアグラーゼ(coagulase)型,薬剤耐性を再検査し,エンテロトキシン(enterotoxin)型(A～D), toxic shock syndrome toxin-1 (TSST-1)産生性を調べ,染色体DNAを制限酵素Sma Iで切断後,パルスフィールド電気泳動(PFGE)を行った。enterotoxin型,TSST-1産生性をcoagulase型と組み合わせると,coagulase II 型, enterotoxin(staphylococcal enterotoxin:SE)C型,TSST-1産生のcoagulase II SE C+TSST-1型が,全866株の49.2%を占めた。地域別にみると,この型が,中部以東では59%以上であったが,近畿では6.9%,中国・四国・九州では21.4～42.0%であった。一方,coagulase II SE A+SE C+TSST-1型が,近畿で34.7%,関東で21.7%,中国で15.7%みられたが,他の地域では9.0%以下であった。PFGE型は,全く同一のものを1種類とした場合,343種類検出された。114種類が複数の株から検出され,うち64種類は一施設内からのみ,50種類は複数の施設から検出された。関東・中部・近畿・九州の4地方9都府県に渡る14施設から82株検出された型や,関東・中部・九州の3地方6都県の12施設から59株検出された型,北海道・関東・中部・中国の4地方7都道県の12施設から28株検出された型もあり,施設や地域を越えて同一菌株が伝播していた可能性が示唆された。また, 5株以上検出された検出頻度の高い28種類のPFGE型の菌株が, 計413株と全866株の47.7%を占めていた。PFGE型が同一の株は,coagulase型,enterotoxin型,TSST-1産生性,薬剤耐性が概ね同じであった。","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"In the early part of the 1990s, hospitals across Japan faced an outbreak of methicillin-resistant Staphylococcus aureus (MRSA) infection. However, it remained unclear whether the same strains spread to different hospitals in different areas, or whether different strains were responsible for each hospital outbreak. Accordingly, in the national MRSA survey conducted from 1992 to 1993, 872 strains were collected in 39 hospitals, and we performed retest for coagulase types and drug resistance, enterotoxin typing (A-D), test for toxic shock syndrome toxin-1 (TSST-1) production and pulse field gel electrophoresis (PFGE) of chromosomal DNA digested with the restriction endonuclease Smal, on 866 well-preserved strains.When enterotoxin and TSST-1 production tests were combined with coagulase test, the coagulase II, enterotoxin(staphylococcal enterotoxin:SE) C, TSST-1-producing coagulase II SE C + TSST-1 types accounted for 42.9% of all the 866 strains. When we investigated the different areas, these types accounted for 59% of all strains east of the Chubu area, but only 6.9% of those in the Kinki area, and 21.4～42.0% of those in the Chugoku, Shikoku and Kyushu areas. Conversely, the coagulase II SE A + SE C + TSST-1 type was found in 34.7% of all strains in the Kinki area, 21.7% in the Kanto area, and 15.7% in the Chugoku area, but less than 9.0% in all other areas.We also detected 343 PFGE types when we counted only those with indistinguishable patterns as one type. Of 114 types which were detected in multiple strains, 64 types were localized to only one hospital, while 50 were identified in multiple hospitals. One PFGE type was detected in 82 strains isolated from 14 hospitals located in 9 prefectures of the Kanto, Chubu, Kinki and Kyushu areas. Another PFGE type was detected in 59 strains isolated from 12 hospitals located in 6 prefectures of the Kanto, Chubu and Kyushu areas, and there was also another type detected in 28 strains isolated from 12 hospitals located in 7 prefectures of the Hokkaido, Kanto, Chubu and Chugoku areas. These indicated the possibility that the same strains spread to different hospitals and different areas. Moreover,there were 28 major PFGE types with a high detection frequency in more than 5 strains. The total number of strains corresponding to these 28 PFGE types was 413, which is 47.7% of all the 866 strains. Strains with the same PFGE type generally had the same coagulase, enterotoxin, TSST-1 production and drug resistance properties.","subitem_description_type":"Other"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA11530249","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Miyazaki Prefectural Nursing University"},{"subitem_text_language":"en","subitem_text_value":"Former Affiliation : Miyazaki Prefectural Nursing University"},{"subitem_text_language":"en","subitem_text_value":"Miyazaki Prefectural Nursing University"},{"subitem_text_language":"en","subitem_text_value":"Miyazaki Prefectural Nursing University"},{"subitem_text_language":"en","subitem_text_value":"Former Affiliation : Miyazaki Prefectural Nursing University,Section of Oncopathology and Regenerative Biology,Faculty of Medicine,University of Miyazaki"},{"subitem_text_language":"en","subitem_text_value":"Pharmaceutical Research Department,Meiji Seika Kaisha,Ltd."},{"subitem_text_language":"en","subitem_text_value":"Miyazaki Prefectural Nursing University"},{"subitem_text_language":"en","subitem_text_value":"Kitasato University"}]},"item_1_text_2":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_text_value":"原著"}]},"item_1_text_3":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Original Article"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"宮崎県立看護大学"},{"subitem_text_value":"元宮崎県立看護大学"},{"subitem_text_value":"宮崎県立看護大学"},{"subitem_text_value":"宮崎県立看護大学"},{"subitem_text_value":"元宮崎県立看護大学,宮崎大学医学部病理学講座腫瘍・再生病態学分野"},{"subitem_text_value":"明治製菓株式会社 医薬総合研究所"},{"subitem_text_value":"宮崎県立看護大学"},{"subitem_text_value":"北里大学"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2009-03-01"}],"displaytype":"detail","filename":"KJ00005673539.pdf","filesize":[{"value":"39.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"url":"https://mpu.repo.nii.ac.jp/record/377/files/KJ00005673539.pdf"},"version_id":"3f9c6e17-7e63-4c11-b2aa-9e2243693827"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"メチシリン耐性黄色ブドウ球菌(MRSA)","subitem_subject_scheme":"Other"},{"subitem_subject":"コアグラーゼ型","subitem_subject_scheme":"Other"},{"subitem_subject":"毒素産生性","subitem_subject_scheme":"Other"},{"subitem_subject":"パルスフィールド電気泳動(PFGE)","subitem_subject_scheme":"Other"},{"subitem_subject":"薬剤耐性","subitem_subject_scheme":"Other"},{"subitem_subject":"methicillin-resistant Staphylococcus aureus (MRSA)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"coagulase type","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"toxin production","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pulsed field gel electrophoresis(PFGE)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"drug resistance","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"日本全国の医療施設から分離されたMRSAの分子疫学的検討 : 施設や地域を越えた同一菌の広がりはあったのか","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"日本全国の医療施設から分離されたMRSAの分子疫学的検討 : 施設や地域を越えた同一菌の広がりはあったのか"},{"subitem_title":"Molecular Epidemiological Study of Methicillin-Resistant Staphylococcus aureus Isolated in Hospitals across Japan : A study investigating whether the same strains spread to different hospitals and different areas","subitem_title_language":"en"}]},"item_type_id":"1","owner":"3","path":["57"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-03-01"},"publish_date":"2009-03-01","publish_status":"0","recid":"377","relation_version_is_last":true,"title":["日本全国の医療施設から分離されたMRSAの分子疫学的検討 : 施設や地域を越えた同一菌の広がりはあったのか"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T07:36:19.657583+00:00"}